Mefenamic Acid and Liver: What You Need to Know

If you’ve been prescribed mefenamic acid for pain, you might wonder how it interacts with your liver. This medicine belongs to the NSAID family, which can put a strain on the liver if not used carefully. Most people take it without problems, but a few can experience liver irritation or higher enzyme levels. Knowing the basics helps you avoid surprise lab results and stay healthy.

How Mefenamic Acid Affects Your Liver

When you swallow mefenamic acid, your liver works to break it down and clear it from the body. In a small percentage of users, this process triggers liver enzymes to rise. Elevated enzymes don’t always mean serious damage, but they signal that the liver is under stress. Risk factors include existing liver disease, heavy alcohol use, and taking other medications that also tax the liver.

Studies show that short‑term use at the recommended dose (usually 250 mg three times a day) rarely causes major liver injury. Problems tend to show up when the drug is taken for weeks or when doses exceed the guidelines. If you notice dark urine, yellow skin, or unusual fatigue, those could be warning signs and you should contact a doctor.

Practical Tips to Protect Your Liver

First, stick to the prescribed dose. Don’t double up just because the pain feels worse. If you need longer relief, ask your provider about alternatives that are easier on the liver, like acetaminophen in moderate amounts.

Second, avoid mixing mefenamic acid with alcohol. Even a few drinks can raise the risk of liver irritation. If you already have a liver condition such as hepatitis or fatty liver, tell your doctor before starting the medication.

Third, keep an eye on lab tests. Your doctor may order liver function tests before you begin treatment and again after a few weeks. Normal results mean you can keep using the drug, while rising enzymes might prompt a dose cut or a switch to another drug.

Finally, support liver health with a balanced diet. Foods rich in antioxidants—like berries, leafy greens, and nuts—help the liver repair itself. Staying hydrated and getting regular exercise also give the organ a boost.

Remember, mefenamic acid can be a helpful pain reliever when used responsibly. By watching your dosage, limiting alcohol, and staying alert to symptoms, you reduce the chance of liver issues and keep the medicine working for you.