ubiquitin In A Sentence
Learn how to use ubiquitin in a sentence and make better sentences with `ubiquitin` by reading ubiquitin sentence examples.
- Then, Ku70 is ubiquitinated by c-Cbl, an E3 ubiquitin ligase.
- The alpha-synuclein-ubiquitin complex cannot be directed to the proteosome.
- NEDD4L belongs to the NEDD4 family of E3 HECT domain ubiquitin ligases.
- Some new type of two-hybrid systems, such as split-ubiquitin system, protein-fragment complementation assay, repressor reconstitution assay and SOS recruitment system, have been developed recently.
- In general, phosphorylation is necessary for the degradation of PERs via ubiquitin ligases.
- Objective To analyze the role and location of ubiquitin-dependent proteolysis pathway(UPP) in PC12 cells transfected by plasmids with spinocerebellar ataxia type 3(SCA3) gene.
- They accept ubiquitin from an E2 conjugating enzyme where they transfer ubiquitin to the RSMADs which causes their ubiquitination and subsequent proteosomal degradation.
- NFE2L1 is also regulated by other ubiquitin ligases and kinases.
- Mdm2 also acts as an E3 ubiquitin ligase, is capable of polyubiquitinating p53.
- The regulatory step affected by phosphorylation could involve either recognition of the substrate by an E3 ubiquitin ligase or the actual conjugation reaction.
- Ubiquitin - proteasome pathway is a highly effective protein - degradation pathway in the eukaryotic cells.
- It contains bactericidal cationic proteins ( e . g . ubiquitin ).
- This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53.
- These included Art Haas, the first to see ubiquitin chains, Keith Wilkinson, a world class enzymologist in many parts of the Ub system.
- The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity.
- This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.
- A particular area of genes that should control the production and function of a protein called ubiquitin is either absent or ineffective.
- Ubiquitin system, a new protein degradation pathway, is regarded as the important one for proteolysis of skeletal muscle.
- By promoting the ubiquitin-mediated degradation of CFTR, Cif is able to phenocopy cystic fibrosis at the cellular level.
- The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis.
- In the case of CASA, dysfunctional, nonnative proteins are recognized by molecular chaperones and become ubiquitinated by chaperone-associated ubiquitin ligases.
- NFAT homodimers are directly responsible for the expression of anergy associated genes such as ubiquitin ligase T-cell, NFAT1, NFAT2 and NFAT4 and apparently are redundant to some extend.
- Dullard helps promote ubiquitin by proteosomal degradation.
- This interaction is crucial for the recruitment of substrates to the ubiquitin ligase complex.
- The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization.
- The ubiquitin-E2 complex is attached to substrate protein by recognition of ubiquitin-protein ligase (E3), then degraded by the 26S proteasome.
- In particular, ubiquitin ligases are shown to be recruited by Numb in mammals.
- Cullin neddylation increases CRL ubiquitylation activity via conformational changes that optimize ubiquitin transfer to target proteins.
- Parkin is a cytosolic E3 ubiquitin ligase.
- It is understood however, is that Co 2 + binding permits ubiquitin binding but prevents proteosomal degradation.
- CUL4B-based E3 ubiquitin ligase complexes often demonstrate overlapping activity with CUL4A-based complexes.
- Ubiquitin-receptor proteins have an three-helix bundles.
- The E3 ubiquitin-protein ligases SMURF1 and SMURF2 regulate the levels of SMADs.
- E6-AP binds ubiquitin to the p53 protein, thereby flagging it for proteosomal degradation.
- The test measures levels of ubiquitin in individual sperm.
- KLF15 upregulates the expression of the E3 ubiquitin ligases SMuRF1 genes and negatively modulates myofiber size.
- The terminal carboxyl of each ubiquitin is linked to the e -amino group of a lysine residue of the adjacent ubiquitin in the chain.
- A second system tags misfolded proteins with a molecule called ubiquitin and carries them to a garbage disposal _ a barrel-shaped structure called the proteosome.
- Ubiquitin ligases transfer ubiquitin to its pendant, proteins, and caspases, which engage in proteolysis in the apoptotic cycle.
- Two ubiquitin ligases are crucial in the cell cycle.
- RBX1 is a core component of Cullin-RING ubiquitin ligase ( CRL ) complexes and functions to recruit E2 ubiquitin conjugating enzymes.
- The gene " MUL1 " encodes one of the E3 ubiquitin ligases.
- FBXW7, a member of the SCF ubiquitin ligase family, targets NFE2L1 for proteolytic degradation by the proteasome.
- KAP1 forms a complex with MDM2 ( a ubiquitin E3 ligase ) that binds to p53.
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